Pervasive Conservation of Intron Number and Other Genetic Elements Revealed by a Chromosome-level Genome Assembly of the Hyper-polymorphic Nematode Caenorhabditis brenneri.

ABSTRACT: With within-species genetic diversity estimates that span the gamut of that seen across the entirety of animals, the Caenorhabditis genus of nematodes holds unique potential to provide insights into how population size and reproductive strategies influence gene and genome organization and evolution. Our study focuses on Caenorhabditis brenneri, currently known as one of the most genetically diverse nematodes within its genus and, notably, across Metazoa. Here, we present a high-quality, gapless genome assembly and annotation for C. brenneri, revealing a common nematode chromosome arrangement characterized by gene-dense central regions and repeat-rich arms. A comparison of C. brenneri with other nematodes from the "Elegans" group revealed conserved macrosynteny but a lack of microsynteny, c

SUBMITTER: Teterina AA 

PROVIDER: S-EPMC11925023 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature