CD161, a promising prognostic biomarker in hepatocellular carcinoma, correlates with immune infiltration.

ABSTRACT:

Background

CD161, encoded by the killer cell lectin-like receptor B1 (KLRB1) gene, exhibits varied roles among different tumors. This study aimed to explore both the potential value of CD161 as a prognostic biomarker for hepatocellular carcinoma (HCC) and its association with immune cell infiltration.

Methods

A total of 109 HCC patients who underwent surgery were retrospectively analyzed. Immunohistochemistry, bioinformatic analyses, and statistical measurements were used to investigate the associations between CD161 expression, immune cell infiltration, and clinical outcomes in both public databases and in-house cohorts.

Results

CD161 was highly expressed at both protein and mRNA levels in adjacent normal tissues compared to tumor tissues of HCC patients. Mean

SUBMITTER: Wang J 

PROVIDER: S-EPMC11925045 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature