Effect of Common Medications on Longitudinal Pectoralis Muscle Area in Smokers.

ABSTRACT:

Background

Cigarette smoke contributes to skeletal muscle wasting. While exercise and nutritional therapies are effective in improving skeletal muscle quantity and quality, the effect of medications on longitudinal muscle loss is unclear. We investigated whether long-term use of common medications affects longitudinal skeletal muscle changes in current and former smokers.

Methods

Using quantitative computed tomography imaging, we measured the 5-year changes in pectoralis muscle area (delta-PMA) and pectoralis muscle density (delta-PMD) of 4191 participants in the COPD Genetic Epidemiology (COPDGene^®) study. We tested whether specific medications were associated with delta-PMA and/or delta-PMD using regression analyses. Propensity score matching (PSM) analysis was

SUBMITTER: Shirahata T 

PROVIDER: S-EPMC11925068 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature