Healthy dietary intake diminishes the effect of cerebral small vessel disease on cognitive performance in older adults.

ABSTRACT:

Introduction

We evaluated whether regular dietary intake of nutrients commonly found in fish, unsaturated oils, and nuts would moderate the associations between neuroimaging biomarkers of cerebral small vessel disease (cSVD) and cognitive function in older adults.

Methods

Dietary information, Montreal Cognitive Assessment (MoCA) scores, and magnetic resonance imaging (MRI) scans were collected from 71 older adults without dementia (60-86 years). MRI biomarkers of cSVD were calculated for each participant. Multivariate linear regression models were computed using dietary intake as the moderating variable. Covariates included age, sex, and estimated intracranial volume.

Results

Dietary intake moderated the association between several cSVD biomarkers and MoCA scores such

SUBMITTER: Bauer CE 

PROVIDER: S-EPMC11925079 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature