Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover study.

ABSTRACT:

Background

Successful seizure onset zone (SOZ) localisation for epilepsy surgery often relies upon intracranial recordings. Accurate delineation requires anatomical detail yet influences of intracranial electrode density on clinical variables have not been systematically studied.

Methods

In this experimental study we compared SOZ localisation between spontaneously captured seizures on higher-density depth and grid electrode arrays (4-5 mm inter-electrode spacing) vs. lower-density resampled versions of those same seizures (8-10 mm spacing). Since traditional review of channel traces would reveal density conditions, we instead projected seizure activity data as heatmaps on patient brain reconstructions and hid electrode locations. Using a single-blinded randomised crossover d

SUBMITTER: Chinedu-Eneh EO 

PROVIDER: S-EPMC11925122 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature