Enhanced oxygen availability and preserved aggregative function in platelet concentrates stored at reduced platelet concentration.

ABSTRACT:

Background

Storage of platelets as platelet concentrates for transfusion is limited to 7 days in the United Kingdom due to deleterious effects on platelet quality and function that occur over time. Oxygen (O₂) availability and sufficient gaseous exchange are known to be essential in maintaining the viability and function of platelets stored for transfusion. Despite this, there is a paucity of studies undertaking direct measures of O₂ and optimization of conditions throughout storage. We address this and modulate the storage conditions to improve platelet quality and function.

Study design and methods

Electron paramagnetic resonance oximetry was implemented to directly measure the [O₂] experienced by stored platelet concentrates and the O

SUBMITTER: Nash J 

PROVIDER: S-EPMC11925141 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature