Plasmid conjugation drives within-patient plasmid diversity.

ABSTRACT: Plasmids are well-known vehicles of antimicrobial resistance (AMR) gene dissemination. Through conjugation, plasmid-encoded AMR genes are spread among neighbouring bacteria, irrespective of their strain or even their species. This process is very concerning from a public health perspective, as plasmid-borne AMR gene outbreaks are often not confined to single species or strains and are therefore more difficult to fully uncover. At the moment, the impact of plasmid conjugation on within-patient plasmid diversity is not well understood. In this work, we will tackle the role of conjugation on within-patient plasmid diversity using a dataset of carbapenemase-producing Enterobacterales. The dataset of 256 sequences originates from bacterial isolates cultured from 115 English patients over

SUBMITTER: Grayson F 

PROVIDER: S-EPMC11925198 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature