NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration.

ABSTRACT:

Purpose

To determine whether bisphosphonate use increases the risk of age-related macular degeneration (AMD), thereby providing evidence for the involvement of the NLRP3 inflammasome in AMD pathogenesis.

Methods

Retrospective cohort study among US veterans who had undergone dual-energy x-ray absorptiometry (DEXA) scans. Time-dependent Cox models were used to assess the association between cumulative bisphosphonate exposure and AMD incidence. Propensity score matching was applied to balance characteristics between bisphosphonate users and nonusers. A secondary analysis examined the impact of NLRP3 inhibitors (fluoxetine and fluvoxamine) on AMD risk among bisphosphonate users.

Results

After propensity score matching, each additional year of bisphosphonate use was associ

SUBMITTER: Magagnoli J 

PROVIDER: S-EPMC11925225 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature