The <i>Salmonella</i> pathogenicity island 1-encoded small RNA InvR mediates post-transcriptional feedback control of the activator HilA in <i>Salmonella</i>.

ABSTRACT: Salmonella Pathogenicity Island 1 (SPI1) encodes a Type-3 secretion system (T3SS) essential for Salmonella invasion of intestinal epithelial cells. Many environmental and regulatory signals control SPI1 gene expression, but in most cases, the molecular mechanisms remain unclear. Many regulatory signals control SPI1 at a post-transcriptional level, and we have identified a number of small RNAs (sRNAs) that control the SPI1 regulatory circuit. The transcriptional regulator HilA activates the expression of the genes encoding the SPI1 T3SS structural and primary effector proteins. Transcription of hilA is controlled by the AraC-like proteins HilD, HilC, and RtsA. The hilA mRNA 5' untranslated region (UTR) is ~350 nucleotides in length and binds the RNA chaperone Hfq

SUBMITTER: Hou Y 

PROVIDER: S-EPMC11925239 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature