On the role of the sorting platform in hierarchical type III secretion regulation in enteropathogenic <i>Escherichia coli</i>.

ABSTRACT: The virulence of enteropathogenic Escherichia coli (EPEC) depends on a type III secretion system (T3SS), a membrane-spanning apparatus that injects effector proteins into the cytoplasm of target enterocytes. The T3SS, or injectisome, is a self-assembled nanomachine whose biogenesis and function rely on the ordered secretion of three distinct categories of proteins: early, middle, and late type III substrates. In EPEC, this hierarchical secretion is assisted by several cytosolic protein complexes at the base of the injectisome. Among these, the sorting platform is involved in the recognition and sequential loading of the different classes of T3-substrates. In addition, a heterotrimeric gatekeeper complex, also known as a molecular switch, operates in concert with components of the T3

SUBMITTER: Marcos-Vilchis A 

PROVIDER: S-EPMC11925242 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature