Quality and stability studies of red blood cell concentrates from umbilical cord blood compared to their adult counterparts.

ABSTRACT:

Background

Prematurity is a significant health issue due to its incidence and associated complications. Anemia is common in extremely preterm infants (EPI) and often requires transfusions. Red blood cells (RBC) from adult blood (AB) donors have been linked to oxygen-related complications in EPI, leading to the exploration of cord blood (CB) as an alternative source. However, standardization of CB-RBC manufacturing and comparison with AB-RBC characteristics are necessary before clinical studies can be conducted.

Materials and methods

This study investigated the quality and characteristics of leukoreduced, gamma-irradiated CB-RBC obtained using a commercial closed system from CB donations not meeting hematopoietic transplantation criteria. CB-RBC units were compared with AB-RB

SUBMITTER: Samarkanova D 

PROVIDER: S-EPMC11925256 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature