RBC-GEM: A genome-scale metabolic model for systems biology of the human red blood cell.

ABSTRACT: Advancements with cost-effective, high-throughput omics technologies have had a transformative effect on both fundamental and translational research in the medical sciences. These advancements have facilitated a departure from the traditional view of human red blood cells (RBCs) as mere carriers of hemoglobin, devoid of significant biological complexity. Over the past decade, proteomic analyses have identified a growing number of different proteins present within RBCs, enabling systems biology analysis of their physiological functions. Here, we introduce RBC-GEM, one of the most comprehensive, curated genome-scale metabolic reconstructions of a specific human cell type to-date. It was developed through meta-analysis of proteomic data from 29 studies published over the past two decades resu

SUBMITTER: Haiman ZB 

PROVIDER: S-EPMC11925312 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature