Comparison of the Effects of Adipose Extracellular Matrix/Stromal Vascular Fraction Gel Injection and CO₂ Fractional Laser on Atrophic Acne Scar in Asians Through a 24-Week Prospective, Randomized, Split-Face Study.

ABSTRACT:

Background

Adipose extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) contains adipose-derived stem cells, extracellular matrix, and other cell components, and possesses the ability to promote collagen production and serve as a filling agent.

Aim

To assess the efficacy and safety of ECM/SVF-gel injection for the treatment of acne scars, compared to CO₂ fractional laser (CO₂FL).

Methods

We performed an open-label, investigator-initiated, assessor-blinded, split-face trial in Xijing Hospital, China, between July 11, 2020, and December 30, 2022. Patients exhibiting moderate to severe acne scars were randomly assigned to a single ECM/SVF-gel injection on one half of the face or two sessions of CO₂FL treatments on the other ha

SUBMITTER: Zhao T 

PROVIDER: S-EPMC11925327 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature