Two long-axis dimensions of hippocampal-cortical integration support memory function across the adult lifespan.

ABSTRACT: The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of its functional integration with neocortex, extending the traditional framework emphasizing functional differences between sharply segregated hippocampal subregions. Yet, it remains unknown whether these modes (i.e. gradients) persist across the adult human lifespan, and relate to memory and molecular markers associated with brain function and cognition. In two independent samples, we demonstrate that the principal anteroposterior and second-order, mid-to-anterior/posterior hippocampal modes of neocortical functional connectivity, representing distinct dimensions of macr

SUBMITTER: Nordin K 

PROVIDER: S-EPMC11925452 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature