Valve cells are crucial for efficient cardiac performance in Drosophila.

ABSTRACT: Blood flow in metazoans is regulated by the activity of the heart. The open circulatory system of insects consists of relatively few structural elements that determine cardiac performance via their coordinated interplay. One of these elements is the intracardiac valve between the aorta and the ventricle. In Drosophila, it is built by only two cells, whose unique histology represents an evolutionary novelty. While the development and differentiation of these highly specialised cells have been elucidated previously, their physiological impact on heart performance is still unsolved. The present study investigated the physiological consequences of cardiac valve malformation in Drosophila. We show that cardiac performance is reduced if valves are malformed or damaged. Less blood is transported

SUBMITTER: Meyer C 

PROVIDER: S-EPMC11925464 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature