Improved overall survival with checkpoint inhibition and allogeneic transplantation in relapsed Hodgkin lymphoma.

ABSTRACT:

Abstract

Patients with relapsed classic Hodgkin lymphomas (cHLs) receive salvage therapy with immune checkpoint inhibitors (ICIs) or chemotherapy (no-ICI). Patients responding to therapy often undergo consolidation with allogeneic blood or marrow transplantation (alloBMT). We previously reported that relapsed patients with cHL treated with ICI followed by alloBMT experienced improved 3-year progression-free survival (PFS) compared with patients treated with salvage chemotherapy without ICI followed by alloBMT. In this retrospective analysis, we report the 5-year overall survival (OS), PFS, and graft-versus-host disease (GVHD) incidence in patients with cHL treated with ICI before alloBMT with post-transplantation cyclophosphamide GVHD prophylaxis. Among the 147 relapsed/refractory

SUBMITTER: Tabbara N 

PROVIDER: S-EPMC11925506 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature