Influence of serum IL-36 subfamily cytokines on clinical manifestations of asthma.

ABSTRACT:

Background

The IL-36 subfamily, a member of the IL-1 superfamily, is thought to promote type 2 (T2) and non-T2 inflammation and involved in autoimmune and airway disease progression. However, its role in asthma remains unclear.

Objective

We sought to determine the contribution of the IL-36 subfamily to the clinical manifestation of asthma.

Methods

The levels of serum IL-36α, IL-36β, and IL-36γ, recognized as IL-36 subfamily agonists, and IL-36 receptor antagonist (IL-36Ra) and IL-38, recognized as IL-36 subfamily antagonists, were measured by ELISA in 110 asthma patients (55 with nonsevere and 55 with severe asthma) aged ≥20 years and 31 healthy individuals. The association of IL-36 with clinical indices and inflammatory mediators was examined. The characteristics of

SUBMITTER: Hoshino Y 

PROVIDER: S-EPMC11925522 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature