CCR3 deficiency shifts adaptive to innate-driven immunity in asthma.

ABSTRACT:

Background

Because of repeated contact with airborne allergens, patients suffering from allergic asthma experience acute asthma attacks, characterized by shortness of breath, chest tightness, and coughing. The underlying immune response is highly complex and involves various immune cells. Chemokines play a pivotal role in the appropriate relocation of these diverse immune cells, ensuring their directed migration to the site of inflammation, their survival, and their effector functions. In the context of allergic asthma, the chemokine receptor CCR3 is crucially involved in T_H2-mediated airway inflammation by recruiting eosinophils and other immune cells to the site of inflammation. However, more recent studies demonstrate its presence also on mast cells, macrophages, T ce

SUBMITTER: Krammer S 

PROVIDER: S-EPMC11925527 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature