Diminished Social Memory and Hippocampal Correlates of Social Interactions in Chronic Social Defeat Stress Susceptibility.

ABSTRACT:

Background

Susceptibility to chronic stress has been associated with depression, a mood disorder that highly implicates the hippocampus. Hippocampal contribution to stress susceptibility has been supported by findings in mice following chronic social defeat stress (CSDS). However, little is known about the role of hippocampal activity in determining the development of stress susceptibility.

Methods

We used the UCLA Miniscope to longitudinally measure the activity of dorsal CA1 hippocampal neurons during CSDS. In addition to examining the representation of social information by these neurons, we compared social memory in mice that were either susceptible or resilient to CSDS.

Results

We observed more stable dorsal CA1 correlates of social interaction and social memory

SUBMITTER: Larosa A 

PROVIDER: S-EPMC11925529 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature