Global estimates of rotavirus vaccine efficacy and effectiveness: a rapid review and meta-regression analysis.

ABSTRACT:

Background

Rotavirus is the leading cause of diarrhoea worldwide, particularly affecting young children. While national rotavirus immunization programs have reduced rotavirus morbidity and mortality, vaccine performance varies considerably between high-income and low-income settings.

Methods

We updated a previous systematic review of studies reporting rotavirus vaccine efficacy and vaccine effectiveness against severe rotavirus-associated gastroenteritis (RVGE) by performing a rapid review from July 1, 2020 through October 16, 2024. We included randomized controlled trials reporting vaccine efficacy against severe RVGE and case-control and cohort studies reporting vaccine effectiveness against hospitalization with RVGE in children <5 years old for current internationally lic

SUBMITTER: Prunas O 

PROVIDER: S-EPMC11925534 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature