Purified fibers in chemically defined synthetic diets destabilize the gut microbiome of an omnivorous insect model.

ABSTRACT: The macronutrient composition of a host's diet shapes its gut microbial community, with dietary fiber in particular escaping host digestion to serve as a potent carbon source for gut microbiota. Despite widespread recognition of fiber's importance to microbiome health, nutritional research often fails to differentiate hyper-processed fibers from cell-matrix-derived intrinsic fibers, limiting our understanding of how individual polysaccharides influence the gut community. We use the American cockroach (Periplaneta americana) as a model system to dissect the response of complex gut microbial communities to dietary modifications that are difficult to test in traditional host models. Here, we designed synthetic diets from lab-grade, purified ingredients to identify how the cockroach mic

SUBMITTER: Dockman RL 

PROVIDER: S-EPMC11925550 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature