Development of an LC-MS/MS Method for Quantifying Occidiofungin in Rabbit Plasma.

ABSTRACT: Fungal infections are caused by opportunistic pathogens that can be life threatening and have been growing in prevalence. Many clinically relevant pathogens have resistance to or are developing resistance to the commonly used antifungal treatments. Occidiofungin (OCF) is a unique cyclic lipoglycopeptide with a novel structure that includes noncanonical amino acid in its covalent structure. It exhibits broad spectrum antifungal activity and has activity against drug resistant Candida species. Occidiofungin is a fungicidal compound that has a novel mechanism of action in which it disrupts higher order actin structures. Currently, occidiofungin is being developed for use in treating vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC). This study describes the developm

SUBMITTER: Cothrell A 

PROVIDER: S-EPMC11925553 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature