Urinary DcR2/Cr level predicts renal outcomes in patients with diabetic kidney disease.

ABSTRACT: In diabetic kidney disease (DKD), urinary decoy receptor 2 (uDcR2) levels are associated with tubulointerstitial fibrosis; however, whether uDcR2 can predict renal outcomes remains unclear. Herein, we analyzed the association between uDcR2 and renal outcomes (defined as a composite of a serum creatinine (SCr) increase of 50 % from baseline, or initiation of dialysis for end-stage renal disease) in 153 patients with biopsy-proven DKD. Patients were divided into the composite (n = 67) and no composite (n = 86) outcome groups. uDcR2 levels were measured using ELISA. The area under the receiver operating characteristic curve (AUC) for uDcR2 in discriminating DKD renal outcomes was calculated. Kaplan-Meier survival analysis and multifactorial Cox regression models evaluated the association betw

SUBMITTER: Chen J 

PROVIDER: S-EPMC11925566 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature