Effective long-term treatment with moss-produced factor H by overcoming the antibody response in a mouse model of C3G.

ABSTRACT: Complement-associated disorders are caused by the dysregulation and disbalance of the complement system, especially excessive activation. Most drugs that target the complement system are designed to inhibit the complement pathway at either the proximal or terminal levels. The use of a natural complement regulator such as factor H (FH) could provide a superior treatment option by restoring balance to an overactive complement system. We recently reported the moss-based production of an analog of human FH with an optimized glycan profile (CPV-104), which showed in vitro and in vivo characteristics comparable to its human counterpart. Here, we follow up our previous work, focusing in more detail on the time course and long-term efficacy of CPV-104 treatment in FH-deficient (FH

SUBMITTER: Tschongov T 

PROVIDER: S-EPMC11925764 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature