<i>Bordetella pertussis</i> infection activates the type I interferon signaling pathway to exacerbate respiratory tract inflammatory response.

ABSTRACT: The upper airway epithelium is the primary site of exposure to Bordetella pertussis and the initiator of host responses to this microbe. B. pertussis may cause serious respiratory infections resulting in major complications, as well as severe impairment of airway function. While pertussis treatment options are limited because the molecular responses in the upper respiratory tract in the early stages of infection have not been characterized. Here, we performed a genome-wide transcriptional analysis of nasal turbinates isolated from mice over 11 days after B. pertussis infection. Using RNA-seq, we characterized the differentially expressed genes and pathways associated with the changes in the nasal turbinates following infection. Statistical analysis revealed that infect

SUBMITTER: Jiang W 

PROVIDER: S-EPMC11925776 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature