PRSS53 is a potential novel biomarker related to prognosis and immunity in clear cell renal cell carcinoma.

ABSTRACT:

Objective

To analyze the expression levels, clinical significance, Immune infiltration and prognostic value of PRSS53 (Protease Serine 53) in clear cell renal cell carcinoma (ccRCC) using bioinformatics methods.

Methods

Data on PRSS53 in ccRCC were extracted from databases and platforms, including The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression Project (GTEx), The Gene Expression Omnibus (GEO), Xiantao Academic Tool, Human Protein Atlas (HPA) and so on. We analyzed the relationship between PRSS53 expression and the clinical and pathological characteristics, diagnosis, immune infiltration and prognosis in ccRCC patients. Additionally, immunohistochemical analysis was performed on 9 pairs of ccRCC patient samples.

Results

PRSS53 was significantly upregulated

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11925835 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature