Apigenin protects ischemic stroke by regulating intestinal microbiota homeostasis, regulates brain metabolic profile.

ABSTRACT:

Background and objective

Ischemic stroke is a cerebrovascular disease with highly incidence. Previous research has demonstrated that apigenin provides protective effects against ischemic stroke. However, it remains unclear whether apigenin can regulate intestinal flora against ischemic stroke.

Methods

In this study, we evaluated the regulatory effects of apigenin on intestinal microbiota using a middle cerebral artery occlusion rat model. The protective impact of apigenin on brain damage in ischemic stroke rats was assessed through Nissl staining, hematoxylin and eosin staining, and immunohistochemistry. Additionally, we employed 16S rRNA sequencing to analyze intestinal contents and utilized non-targeted metabolomics to investigate the effects of apigenin on brain metabolit

SUBMITTER: Li J 

PROVIDER: S-EPMC11925864 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature