Characterization of carbapenem-resistant <i>Klebsiella pneumoniae</i> in bloodstream infections: antibiotic resistance, virulence, and treatment strategies.

ABSTRACT:

Background

Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections pose a major clinical challenge due to multidrug resistance. This study evaluated the clinical features, antibiotic resistance mechanisms, virulence factors, and the potential therapeutic impact of berberine hydrochloride (a traditional Chinese medicine) in CRKP infections.

Methods

Ninety-four CRKP isolates from bloodstream infections at the First Affiliated Hospital of Zhejiang Chinese Medical University were characterized for carbapenemase genes, antibiotic susceptibility, and virulence determinants. Clinical data were analyzed to identify risk factors for CRKP infection, and the in vitro antibacterial activity of berberine hydrochloride was assessed.

Results

Most of the isolates (

SUBMITTER: Zhong C 

PROVIDER: S-EPMC11925884 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature