Antibiotics-induced dysbiosis impacts dendritic morphology of adult mouse cortical interneurons.

ABSTRACT:

Introduction

A growing body of evidence suggests that the gut microbiome may contribute to changes in brain morphology. The microbiota-gut-brain axis (MGBA) has been shown to influence neurogenesis, axon myelination, and synapse structure. However, it remains unclear whether the MGBA can influence the morphology and density of inhibitory GABAergic interneurons. The aim of this study was to determine whether antibiotic-induced dysbiosis (AID) is associated with alterations in dendritic morphology of GABAergic inhibitory interneurons in the medial entorhinal cortex (mEC), somatosensory cortex (SSC), motor cortex (MC), and hippocampus (Hp).

Methods

A cohort of six-month-old GAD-67-EGFP transgenic mice was treated with an antibiotic cocktail for two weeks, resulting in gut dysbi

SUBMITTER: Nakhal MM 

PROVIDER: S-EPMC11925899 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature