Effect of four traditional Chinese medicine monomers on mechanical barrier damage and inflammation response of IPEC-J2 cells caused by soybean 7S globulin.

ABSTRACT:

Introduction

The soybean 7S globulin is a major allergen responsible for diarrhea in weaned piglets, leading to significant economic loss in the pig breeding industry. Therefore, there is an urgent need to find effective and safe therapeutic agents to prevent and treat diarrhea caused by soybean 7S globulin. Given the global trend toward "antibiotic alternatives," traditional Chinese medicines (TCMs) offer a promising approach for the prevention and control of animal diseases.

Methods

In this study, four TCM monomers (curcumin, eleutheroside E, saponin B4, and forsythia A) were evaluated for their protective and therapeutic effects on intestinal epithelial cells (IPEC-J2) damaged by soybean 7S globulin. The CCK8 assay, western blot assay, Elisa assay, and PCR assay were used

SUBMITTER: Deng Y 

PROVIDER: S-EPMC11925905 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature