Morphology and biomechanical index predict the rupture location and rupture risk of abdominal aortic aneurysm.

ABSTRACT: The integration of biomechanical and morphological analyses holds tremendous potential for assessing the rupture risk of abdominal aortic aneurysms (AAA). We employed a one-way fluid-structure interaction (FSI) model to distinguish between ruptured AAA (RAAA) and asymptomatic intact AAA (IAAA), focusing on morphological and computational fluid dynamics (CFD) indices. Patient groups with ruptured RAAA and asymptomatic IAAA were matched by diameter, age, and sex. AAA morphology was analyzed via CT segmentation, and biomechanical indices-including wall shear stress (WSS), peak wall stress (PWS), maximum deformation (MD), and other indices-were determined using FSI analysis. Statistical comparisons were performed using paired t-tests or Wilcoxon rank sum tests. Multivariate and LASSO regressio

SUBMITTER: Liu T 

PROVIDER: S-EPMC11926079 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature