High disease activity correlate with decreased serum calcium in systemic lupus erythematosus.

ABSTRACT: We evaluated the clinical and laboratory features of decreased serum calcium (albumin corrected or uncorrected) compared to non-hypocalcemia in SLE patients. Exploring the value of serum calcium in assessing the activity and prognosis of SLE disease. Retrospective analysis and comparison of clinical and laboratory data obtained during the treatment period of SLE patients from 2018 to 2023. Both quantity and titer of serum anti-dsDNA antibodiesin SLE patients with hypocalcemia were significantly increased, and peripheral leucocytes, platelets, complement C3 or C4 reduced, while urinary cast and 24 h urine protein elevated. SLEDAI-2 K, BILAG and PGA have confirmed that SLE patients with decreased serum calcium had stronger disease activity, even without positive titers of anti-dsDNA antibodi

SUBMITTER: Du X 

PROVIDER: S-EPMC11926091 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature