Cytoplasmic retention of dengue virus capsid protein by metformin impairing nuclear transport.

ABSTRACT: Nuclear transport of proteins larger than 60 kDa occurs via energy-dependent active transport, whereas smaller proteins diffuse into the nucleus through nuclear pore complexes via passive nuclear transport. Although the dengue virus (DENV) replication cycle primarily takes place in the cytoplasm, the capsid protein and non-structural protein 5 (NS5) are imported into the nucleus through a nuclear localization sequence-dependent mechanism. However, given its small molecular weight (14 kDa), the DENV capsid protein may also enter the nucleus via passive diffusion. While some drugs primarily inhibit active nuclear transport, few are known to block passive diffusion. Notably, biguanides have been associated with inhibitory effects on passive nuclear transport. Since biguanides such as metformi

SUBMITTER: Puello-Nakayama IC 

PROVIDER: S-EPMC11926096 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature