Circadian phase inversion causes insulin resistance in a rat model of night work and jet lag.

ABSTRACT: Shift workers have an increased risk to develop type 2 diabetes. We aimed to investigate the underlying mechanisms and the role of the timing of food intake by subjecting rats to an acute phase inversion of the light/dark (L/D) cycle. In the first experiment, with food available ad libitum, male Wistar rats were implanted with jugular vein catheters and intravenous glucose tolerance tests were performed at either ZT2 or ZT14. Three days after the 12 h phase shift, these glucose tolerance tests were repeated. In the second experiment, rats were housed in metabolic cages for the continuous measurement of multiple behavioral and metabolic parameters after the 12 h phase shift, food was available ad libitum or restricted to the light or dark period. The daily rhythm of glucose tolerance, and t

SUBMITTER: Wang A 

PROVIDER: S-EPMC11926194 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature