Prevalence and distribution of Plasmodium falciparum multidrug resistant 1 D1246Y allele among children in Ibadan Southwest, Nigeria.

ABSTRACT: The emergence and spread of the Plasmodium falciparum multidrug-resistant 1 (Pfmdr1) allele pose a significant setback to global efforts to control and eradicate malaria infection by diminishing the efficacy of commonly prescribed antimalarial drugs, particularly in Sub-Saharan Africa, where malaria remains endemic. The Pfmdr1 D1246Y mutation is of specific importance due to its potential role in modulating parasite susceptibility to antimalarial medicines and treatment outcomes. This study aimed to determine the presence and prevalence of the wild-type and mutant D1246Y alleles of Pfmdr1 among children in Ibadan, Southwest Nigeria. A total of 133 archived DNA samples collected between March 2016 and June 2021 from children aged 6 to 132 months with varying malaria phenotypes (asymptomatic

SUBMITTER: Patrick OJ 

PROVIDER: S-EPMC11926228 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature