Differential large-scale network functional connectivity in cocaine-use disorder associates with drug-use outcomes.

ABSTRACT: Cocaine-use disorder (CUD) affects both structure and function of the brain. A triple network model of large-scale brain networks has been useful for identifying aberrant resting-state functional connectivity (rsFC) associated with mental health disorders including addiction. The present study investigated differences between people with CUD vs. controls (CONs) and whether putative differences were associated with drug-use outcomes. Participants with CUD (n = 38) and CONs (n = 34) completed a resting functional magnetic resonance imaging (fMRI) scan. Participants with CUD completed several mental health measures and participated in an 8-week, drug-use outcomes phase. A classification framework based on the triple network model was built, and triple networks (salience [SN], executive contro

SUBMITTER: Regier PS 

PROVIDER: S-EPMC11926260 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature