Enhanced glomerular thrombosis in pronated animals with ARDS.

ABSTRACT:

Background

Prone positioning is part of the management of acute respiratory distress syndrome (ARDS) and has been demonstrated to successfully improve the ventilation-perfusion match and reduce mortality in patients with severe respiratory failure. However, the effect of pronation on other organs than the lungs has not been widely studied. This study aimed to compare abdominal edema, perfusion and inflammation in supine and prone positioning in a porcine ARDS model.

Methods

Seventeen piglets were randomized into two groups: a supine group (n = 9) and a prone group (n = 8). Both groups received endotoxemic infusion and were observed for 6 h. Three animals per group underwent positron emission tomography-magnetic resonance imaging (PET-MRI) for imaging acquisition. Hemodynamic

SUBMITTER: Marchesi S 

PROVIDER: S-EPMC11926287 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature