Resting-State Functional Interactions Between the Action Observation Network and the Mentalizing System.

ABSTRACT: Human social functioning is thought to rely on the action observation network (AON) and the mentalizing system (MS). It is debated whether AON and MS are functionally separate or if they interact. To this end, we combined resting-state connectivity with task-based fMRI to characterize the functional connectome within and between these systems. In detail, we computed resting-state connectivity within and between the AON and MS using single subject-defined regions of interest (ROIs). Our results showed a positive coupling between ROIs within each system and negative coupling between the two systems, supporting the existence of two independent networks at rest. Still, two regions (pSTS, aIFG) showed hybrid coupling, connecting with regions of both systems, suggesting that they might mediate c

SUBMITTER: Simone L 

PROVIDER: S-EPMC11926297 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature