Effects of Emissions From Oriented Strand Board on the Development of Atopic Dermatitis Using Two Different Experimental Mouse Models.

ABSTRACT: Atopic dermatitis (AD) is an allergic skin disease widespread in children, which later in life can predispose them to asthma. Oriented strand board (OSB), increasingly used in the construction industry, emits volatile organic compounds in the indoor air, some of which may exacerbate AD development in humans. The aim of this study was to evaluate the effects of OSB emissions on the development of AD and lung inflammation. Two different murine AD models, induced by calcipotriol or oxazolone, were exposed to higher- or lower-emitting OSB throughout the experiments. Physiological, biochemical, and immunological parameters of skin disease development, as well as lung inflammatory parameters, were evaluated. Exposure to higher-emitting OSB, characterised especially by high 3-carene emissions, ex

SUBMITTER: Schneider E 

PROVIDER: S-EPMC11926298 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature