High-efficiency [¹⁸F]fluoride pre-concentration using a laser-micromachined anion-exchange micro-cartridge.

ABSTRACT:

Background

The use of radiopharmaceuticals labelled with fluorine-18 in non-invasive imaging, particularly in Positron Emission Tomography (PET), increased significantly during the last decade. However, traditional nucleophilic fluorination synthesis methods in most cases require azeotropic drying steps, leading to loss of activity and increased synthesis time. Microfluidic devices offer improvements with shorter reaction times, higher elution efficiency, and reduced reagent quantities.

Results

We developed a novel micro-cartridge for [¹⁸F]fluoride trapping and elution, etched in borosilicate optical glass (BK7) using ultrashort laser pulse machining. The micro-cartridge has a bead volume of 17 µL and a maximum capacity of 8.5 mg for anion exchange resin. The micr

SUBMITTER: Gomes AA 

PROVIDER: S-EPMC11926312 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature