Cortico-subcortical networks that determine behavioral memory renewal are redefined by noradrenergic neuromodulation.

ABSTRACT: During spatial appetitive extinction learning (EL), rodents learn that previously rewarded behavior is no longer rewarded. Renewal of the extinguished behavior is enabled by re-exposure to the context in which rewarded learning occurred. When the renewal response (RR) is unrewarded, it is rapidly followed by response extinction (RE). Although the hippocampus is known to be engaged, whether this dynamic is supported by different brain networks is unclear. To clarify this, male rats engaged in context-dependent spatial memory acquisition, EL and RR testing in a T-Maze. Fluorescence in situ hybridization disambiguated somatic immediate early gene expression in neuronal somata engaged in RR or RE. Graph analysis revealed pronounced hippocampal connectivity with retrosplenial and prefrontal cor

SUBMITTER: Haubrich J 

PROVIDER: S-EPMC11926362 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature