Dopaminergic changes in the subgenual cingulate cortex in dementia with lewy bodies associates with presence of depression.

ABSTRACT: In addition to the core clinical features of fluctuating cognition, visual hallucinations, and parkinsonism, individuals with dementia with Lewy bodies (DLB) frequently experience chronic and debilitating major depression. Treatment of depression in DLB is hampered by a lack of available effective therapies and standard serotonergic medication for major depressive disorder (MDD) is typically ineffective. Dysfunction of dopaminergic neurotransmission contributing to anhedonia and loss of motivation has been described in MDD. The subgenual anterior cingulate cortex (sgACC) is important in mood regulation and in the symptomatic expression of depression, displaying structural, functional and metabolic abnormalities in MDD. To assess dopaminergic and serotonergic synaptic changes in DLB, post m

SUBMITTER: Gliaudelyte L 

PROVIDER: S-EPMC11926374 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature