RNA m7G methylation regulators and targets significantly contribute to chronic obstructive pulmonary disease.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is one of the most common lung injury diseases, closely associated with aging, air pollution and smoking exposure. The novel epigenetic modification 7-methylguanosine (m7G) RNA methylation affects the pathogenesis and progression of COPD. In this study, the combined roles of m7G methylation regulators were explored in COPD for the first time by integrated bioinformatic methods. The machine algorithms screened 7 disease signature genes relevant to clinical indicators, including CYFIP2, EIF3D, EIF4G3, GEMIN5, METTL1, SNUPN and NCBP2, and METTL1 was related to the progression in COPD. COPD patients could be well divided into two m7G subtypes by consensus clustering, and the two groups had differential immune profiles, visualized by single-cell sequ

SUBMITTER: Zhu C 

PROVIDER: S-EPMC11926379 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature