Association between De-Ritis ratio (AST/ALT) and mortality in patients with chronic kidney disease: a retrospective cohort study.

ABSTRACT: The De-Ritis ratio, also known as the aspartate aminotransferase-to-alanine aminotransferase ratio (AST/ALT ratio), has been associated with poor outcomes in critically ill patients. However, data on chronic kidney disease (CKD) patients are lacking. Herein, we aimed to assess the association between De-Ritis ratio and mortality among American CKD patients. We conducted a retrospective cohort study that included 2728 individuals from the National Health and Nutrition Examination Survey (2007-2016). Participants were stratified based on the tertiles of De-Ritis ratios. The association was investigated employing the multivariate cox proportional hazard regression model. The all-cause mortality and cardiovascular disease (CVD) mortality were 24.2% (659/2728) and 5.8% (157/2728), respectively.

SUBMITTER: Li Q 

PROVIDER: S-EPMC11926390 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature