E7HPV16 Oncogene and 17beta-Estradiol Stress, Promotes Oncogenic microRNA Expression Patterns, Cell Proliferation and Cervical Intraepithelial Neoplasia 1.

ABSTRACT: Cervical cancer (CC) is the second cause of death by a neoplasia in woman in Mexico. Among the factors that contribute to its development are prolonged infection by a high-risk HPV type and the use of estrogens. It is well known that diagnosis at early stages is extremely important since, in most cases, progression towards carcinogenesis could be prevented, hence the importance of finding candidates that serve as early biomarkers. Several studies have shown that the expression level of the tumor suppressor miR-218 is diminished in CC while oncomiR miR-21 is overexpressed. On the other hand, it has been reported that the Potassium calcium-activated channel subfamily M alpha 1 (Kcnma1) oncogene, a known target gene of miR-218, is overexpressed in CC. However, there are few studies on the exp

SUBMITTER: Arvizu-Hernandez E 

PROVIDER: S-EPMC11926415 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature