Potential of automated online adaptive proton therapy to reduce margins for oesophageal cancer.

ABSTRACT:

Background and purpose

Proton therapy for oesophageal cancer is administered over multiple fractions, based on a single pre-treatment image. However, anatomical changes can lead to the deterioration of the treatment plan, necessitating manual replanning. To keep this within limits, increased residual margins are employed. This study aimed to evaluate the proposed automated Online Adaptive Proton Therapy (OAPT) strategies on their capability to reduce the need for manual replanning, while also exploring the possibility of margin reduction.

Materials and methods

Two automated OAPT methods were examined: Automated Dose Restoration (ADR) and Automated Full Adaptation (AFA). ADR makes use of dose restoration, restoring the original dose map based on the patient's altered anatomy.

SUBMITTER: Herbst P 

PROVIDER: S-EPMC11926429 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature