Uncertainty estimation in female pelvic synthetic computed tomography generated from iterative reconstructed cone-beam computed tomography.

ABSTRACT:

Background and purpose

Iterative reconstruction (IR) can be used to improve cone-beam computed tomography (CBCT) image quality and from such iterative reconstructed (iCBCT) images, synthetic CT (sCT) images can be generated to enable accurate dose calculations. The aim of this study was to evaluate the uncertainty in generating sCT from iCBCT using vendor-supplied software for online adaptive radiotherapy.

Materials and methods

Projection data from 20 female pelvic CBCTs were used to reconstruct iCBCT images. The process was repeated with 128 different IR parameter combinations. From these iCBCTs, sCTs were generated. Voxel value variation in the 128 iCBCT and 128 sCT images per patient was quantified by the standard deviation (STD). Additional sub-analysis was performed per

SUBMITTER: de Hond YJM 

PROVIDER: S-EPMC11926433 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature