Gut Microbial Metabolites and Future Risk of Parkinson's Disease: A Metabolome-Wide Association Study.

ABSTRACT:

Background

Alterations in gut microbiota are observed in Parkinson's disease (PD). Previous studies on microbiota-derived metabolites in PD were small-scale and post-diagnosis, raising concerns about reverse causality.

Objectives

Our goal was to prospectively investigate the association between plasma microbial metabolites and PD risk within a metabolomics framework.

Methods

A nested case-control study within the prospective EPIC4PD cohort, measured pre-diagnostic plasma microbial metabolites using untargeted metabolomics.

Results

Thirteen microbial metabolites were identified nominally associated with PD risk (P-value < 0.05), including amino acids, bile acid, indoles, and hydroxy acid, although none remained significant after multiple testing correction. Thre

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11926468 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature