A Versatile Method to Produce Monomodal Nano- to Micro-Fiber Fragments as Fillers for Biofabrication.

ABSTRACT: A key goal of biofabrication is the production of 3D tissue models with biomimetic properties. In natural tissues, fibrils-mainly composed of collagen-play a critical role in stabilizing and spatially organizing the extracellular matrix. To use biomimetic fibers for reinforcing bioinks in 3D printing, fiber fragmentation is necessary to prevent nozzle clogging. However, existing fragmentation methods are often material-specific, poorly scalable, and provide limited control over fragment size and shape. A novel workflow is introduced for producing fiber fragments applicable to various materials and fabrication techniques such as electrospinning, melt-electrowriting, fused deposition modeling, wet spinning, and microfluidic spinning. The method uses a sacrificial membrane as a substrate for

SUBMITTER: Lamberger Z 

PROVIDER: S-EPMC11926501 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature