Prospective Multicenter Evaluation of the MDS "Suggestive of PSP" Diagnostic Criteria.

ABSTRACT:

Background

The recent Movement Disorders Society (MDS)-progressive supranuclear palsy (PSP) diagnostic criteria conceptualized three clinical diagnostic certainty levels: "suggestive of PSP" for sensitive early diagnosis based on subtle clinical signs, "possible PSP" balancing sensitivity and specificity, and "probable PSP" highly specific for PSP pathology.

Objective

The aim of this study was to prospectively validate the criteria against long-term clinical follow-up and characterize the diagnostic certainty increase over time.

Methods

Patients with "possible PSP" or "suggestive of PSP" diagnosis and clinical follow-up were recruited in two German multicenter longitudinal observational studies (ProPSP and DescribePSP). The cumulative percentage of patients longitudin

SUBMITTER: Quattrone A 

PROVIDER: S-EPMC11926504 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature